Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats.

Effects of Saffron and its Active Constituents, Crocin and Safranal, on Prevention of Indomethacin Induced Gastric Ulcers in Diabetic and Nondiabetic Rats

  Background: Saffron is the dried stigmata of the flowers of saffron (Crocus sativus L., Iridaceae). Saffron is well known for the treatment of gastric disorders in traditional medicine.   Objectives: In the search for new potential antiulcer agents, the effects of the ethanol extract of saffron and its active constituents crocin and safranal as compared with omeprazole against gastric ulcer i...

The protective action of melatonin on indomethacin-induced gastric and testicular oxidative stress in rats. Reactive oxygen species and lipid peroxidation play a role in the pathogenesis induced by the nonsteroidal anti-inflammatory drug indomethacin. Melatonin (MLT) protection against indomethacininduced

The protective action of melatonin on indomethacin-induced gastric and testicular oxidative stress in rats. Reactive oxygen species and lipid peroxidation play a role in the pathogenesis induced by the nonsteroidal anti-inflammatory drug indomethacin. Melatonin (MLT) protection against indomethacininduced

L-carnitine inhibits ethanol-induced gastric mucosal injury in rats.

L-carnitine is a quaternary amine that is essential for the normal oxidation of long-chain fatty acids by mitochondria. It is known that L-carnitine and its derivatives prevent the formation of reactive oxygen species, scavenge free radicals and protect cells from peroxidative stress. Oxygen-derived free radicals and lipid peroxidation products play a critical role in the pathogenesis of ethano...

Biol. Pharm. Bull. 29(4) 675—683 (2006)

tion of connective tissue mast cells, but not mucosal mast cells, with release of serotonin and histamine from the cells. We have shown in rats with a single C48/80 treatment that the development of gastric mucosal lesions occurs with decreases in Se-glutathione peroxidase (Se-GSHpx) activity and vitamin E and hexosamine levels and increases in neutrophil infiltration, xanthine oxidase (XO) act...